Science 7 February 2014:
Vol. 343 no. 6171 pp. 624-625
DOI:10.1126/science.1250244
Perspective

Cells Listen to Their Inner Voice

Anna Jisu Lee, Lingchong You | 1 Comments

A signaling circuit that controls the release and detection of the same signaling molecule can trigger diverse behaviors in a cell population. [Also see Research Article by Youk and Lim]

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Re: Similar dynamics may occur in the natural setting, resulting from signaling networks built around the same core secrete-and-sense regulatory motif."

That fact was detailed in "Signaling Crosstalk: Integrating Nutrient Availability and Sex." http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/291/pe28

The author noted that: "The mechanism by which one signaling pathway regulates a second provides insight into how cells integrate multiple stimuli to produce a coordinated response."

In mammals, that signaling pathway is exemplified by the gonadotropin releasing hormone (GnRH) neuronal system. It links food odors and social odors called pheromones from the epigenetic landscape to the physical landscape of DNA via subtle changes in GnRH pulse frequency and amplitude.

The molecular epigenetics of biologically-based cause and effect appear to be conserved in species from microbes to man. This new evidence adds substantial weight to a model of nutrient-dependent pheromone-controlled ecological adaptations.

That model infuriates some evolutionary theorists because it refutes mutation-initiated natural selection. It makes obvious the fact that 1) natural selection is for nutrients, and 2)the nutrients metabolize to species-specific pheromones, which control the physiology of reproduction.

Mutations perturb the protein folding that is required for increased organismal complexity to arise from nutrient-dependent pheromone-controlled amino acid substitutions that stabilize protein folding in the context of ecological, social, neurogenic, and socio-cognitive niche construction.

To my knowledge no experimental evidence links mutations to de novo creation of genes and chromosomal rearrangements or to niche construction, which is why biological plausibility and ecological validity favor a model of nutrient-dependent pheromone-controlled adaptations to ever-changing epigenetic landscapes in all species.

Submitted on Thu, 02/06/2014 - 22:32