Science 22 November 2013:
Vol. 342 no. 6161 pp. 976-979
DOI:10.1126/science.1244730
Report

Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

Björn F. Koel, David F. Burke, Theo M. Bestebroer, Stefan van der Vliet, Gerben C. M. Zondag, Gaby Vervaet, Eugene Skepner, Nicola S. Lewis, Monique I. J. Spronken, Colin A. Russell, Mikhail Y. Eropkin, Aeron C. Hurt, Ian G. Barr, Jan C. de Jong, Guus F. Rimmelzwaan, Albert D. M. E. Osterhaus, Ron A. M. Fouchier, Derek J. Smith | 1 Comments

The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.

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